Which of the following should be avoided to ensure safety while driving?

Driving late at night should be avoided to ensure safety because visibility is significantly reduced during these hours, making it harder to see potential hazards such as pedestrians, cyclists, or road obstacles. Additionally, nighttime driving can lead to increased fatigue levels, as many people experience natural dips in alertness during the night. This can impair reaction times and decision-making abilities, leading to a greater likelihood of accidents.

In comparison, taking regular breaks, using lights and sirens when necessary for emergency response, and maintaining a clear route are all practices that promote safety. Regular breaks help prevent fatigue, using lights and sirens alerts other drivers and pedestrians to the emergency vehicle's presence, and ensuring a clear route minimizes obstacles that could lead to accidents. Thus, while nighttime driving can pose particular challenges, the other options enhance safety in various ways.